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NMDA-type Glutamate Receptor (NMDA-R)
- Target
- NMDA-R
- Molecular classification
- Ion channel, Ligand-gated ion channel, Receptor, Glutamate receptor
01
Overview
The NMDA-type glutamate receptor (NMDA-R) is a subtype of ionotropic glutamate receptors that functions as a ligand-gated ion channel. It plays a central role in excitatory neurotransmission in the central nervous system and is crucial for synaptic plasticity, learning, and memory formation. Activation requires simultaneous binding of glutamate and glycine/D-serine. The receptor is blocked by Mg²⁺ at resting membrane potentials. NMDA receptors are implicated in numerous neurological disorders.
- Other names
- N-methyl-D-aspartate receptorNMDARGlutamate receptor, NMDA type
02
Mechanism of action
Allosteric modulation; Channel blockade
03
Biological functions
Excitatory neurotransmissionSynaptic plasticityLearningMemory formationCalcium signalingIon transport
04
Disease associations
Ischemic strokeTraumatic brain injuryAlzheimer’s diseaseEpilepsyMood disordersSchizophreniaNeurodegenerative disease
05
Safety considerations
Excessive excitation/toxicityImpaired signalingNeuroprotection/neuropsychiatric intervention challenges
06
Interacting drugs
Memantine
1 more in the full profile.
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