NmrA like redox sensor 2 pseudogene (NMRAL2P)

NMRAL2P, or NmrA like redox sensor 2 pseudogene, is a non-protein-coding RNA gene derived from the NmrA redox sensor family and functions as a direct transcriptional target of the Nrf2 antioxidant response pathway in human cells. It operates as a functional pseudogene with regulatory activity, serving as a coactivator that enhances Nrf2-induced expression of genes such as NQO1. NMRAL2P is upregulated by chemopreventive agents like sulforaphane in the nucleus and cytoplasm and participates in the maintenance of cancer-related cellular processes, including growth and migration. Unlike classical receptors or enzymes, NMRAL2P does not encode a functional protein and is not considered a direct therapeutic target; however, it may serve as a biomarker or a modulator in diseases with dysregulated redox homeostasis and cancer.

Other names

NMRAL1P1NmrA like redox sensor 1 pseudogene 1NmrA-like family domain containing 1 pseudogeneLoc344887

Induction by Nrf2 upon oxidative or chemopreventive stimuli (such as SFN), leading to enhanced expression of antioxidant target genes like NQO1 via NMRAL2P coactivator function.