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No direct molecular target
01
Overview
The phrase "No direct molecular target" indicates that, despite biological or pharmacological effects observed for a given compound, there is no evidence of a specific protein or biomolecule to which the compound binds directly with high specificity or affinity, nor a validated target responsible for its activity[1][2][3][6]. This is a frequent situation in drug discovery when either the mechanism of action is unknown, or a molecule acts broadly through many weak interactions rather than one dominant, targetable protein. This entry is not suitable for inclusion as a therapeutic target in structured databases as it does not specify a molecular entity.
- Other names
- No direct binding targetNo validated molecular targetNo demonstrated molecular target
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