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NOC2 like nucleolar associated transcriptional repressor (NOC2L)
- Target
- NOC2L
- Molecular classification
- Transcription factor, Histone modification (INHAT - Inhibitor Of Histone Acetyltransferase)
01
Overview
NOC2 like nucleolar associated transcriptional repressor (NOC2L) is a protein involved in gene silencing through inhibition of histone acetyltransferases, notably EP300/p300, at p53-regulated promoters. Unlike classical histone deacetylases, NOC2L functions as a HDAC-independent INHAT repressor, preventing the acetylation of core histones and modulating the activity of key cell cycle and apoptosis regulators, including p53 and TP63. NOC2L is primarily localized in the nucleolus and nucleoplasm; it is not currently considered a pharmacological therapeutic target but is studied for its fundamental roles in transcriptional regulation and some genetic diseases such as Epiphyseal Chondrodysplasia, Miura Type.
- Other names
- Nucleolar complex protein 2 homologProtein NOC2 homologNOC2-like proteinDKFZP564C186Novel INHAT (inhibitor of histone acetyltransferase) repressorNucleolar complex associated 2 homologNET7NET15NIRPPP1R112
02
Mechanism of action
No drugs reported; its biological action is inhibition of histone acetyltransferase activity via the INHAT mechanism rather than being a pharmacological target
03
Biological functions
Transcriptional repression (by blocking histone acetylation via EP300/p300 inhibition)Regulation of p53/TP53-dependent apoptosis and cell cycle (p21/CDKN1A promoter repression)RNA bindingRegulation of gene expression (TP53 and TP63 targets)Inhibition of histone acetyltransferases (HDAC-independent)Other (nucleolar function)
04
Disease associations
Epiphyseal chondrodysplasia, Miura Type (association cited)Other (no widely validated roles in major diseases as therapeutic target)
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