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Target intelligence / Profile preview
NOC3 like DNA replication regulator (NOC3L)
- Target
- NOC3L
- Molecular classification
- Other (DNA replication regulator, chromatin-associated protein)
01
Overview
NOC3 like DNA replication regulator (NOC3L) is a protein-coding gene encoding a human homolog of yeast Noc3p. It is involved in initiating DNA replication and is predicted to enable RNA binding and chromatin binding activities. NOC3L acts upstream of biological processes such as fat cell (adipocyte) differentiation and may be required for adipogenesis. It is located in cellular compartments including the mitochondrion, nucleolus, and nucleoplasm. Diseases associated with NOC3L include nephrotic syndrome and brachydactyly; research also implicates potential roles in cancer due to its ties to cell proliferation and DNA replication[1][2][4][8][9][10]. No approved drugs currently target NOC3L, and it is not a therapeutic target as of current knowledge[1][8][9][10].
- Other names
- Nucleolar complex protein 3 homologAD24C10orf117FAD24FLJ12820factor for adipocyte differentiation 24NOC3-like proteinnucleolar complex-associated protein 3-like protein
02
Biological functions
DNA replication initiationfat cell (adipocyte) differentiationRNA bindingchromatin binding
03
Disease associations
CancerNephrotic syndromeBrachydactyly
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