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Target intelligence / Profile preview
Nociceptin/Orphanin FQ Peptide Receptor (NOP)
- Target
- NOP
- Molecular classification
- G protein-coupled receptor, Receptor, Opioid receptor family
01
Overview
The nociceptin/orphanin FQ peptide receptor (NOP), also known as ORL1 or kappa-type 3 opioid receptor, is a G protein-coupled receptor belonging to the opioid receptor family. It is activated by its endogenous ligand nociceptin/orphanin FQ (N/OFQ). NOP plays a role in various physiological functions, including pain modulation, mood regulation, blood pressure control, and immune modulation. Due to these roles, it is a therapeutic target for analgesia, depression, Parkinson’s disease, and alcohol addiction.
- Other names
- ORL1kappa-type 3 opioid receptorNociceptin opioid peptide receptor
02
Mechanism of action
Activation of G protein signaling pathways; biased agonism (G protein or β-arrestin)
03
Biological functions
Pain modulationMood regulationBlood pressure controlImmune modulationAirway constrictionFeeding behaviorUrination and bowel motilityLearning and memory processesSignal transduction
04
Disease associations
PainDepressionParkinson’s diseaseAlcohol addictionAnxietyCough
05
Safety considerations
Complex pain modulation (pronociceptive or antinociceptive depending on location and dose)Potential for side effects related to broad physiological roles
06
Interacting drugs
Nociceptin/orphanin FQ (N/OFQ)
4 more in the full profile.
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