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Target intelligence / Profile preview
NOD-like receptor family pyrin domain-containing protein 3 inflammasome complex (None)
- Target
- None
- Molecular classification
- Multiprotein complex, Inflammasome
01
Overview
The NLRP3 inflammasome is a cytosolic multiprotein complex that plays a central role in the innate immune system by detecting pathogenic microorganisms and cellular damage, thereby initiating inflammatory responses. It consists of the sensor NLRP3, the adaptor ASC, and the effector pro-caspase-1. Activation leads to the maturation and release of IL-1β and IL-18, as well as pyroptosis via gasdermin D. Aberrant activation is implicated in numerous diseases.
02
Mechanism of action
Inhibition of NLRP3 inflammasome activation
03
Biological functions
Immune responseInflammationCytokine maturationPyroptosisHost defense
04
Disease associations
GoutAtherosclerosisNeurodegenerative diseaseAlzheimer’s diseaseType 2 diabetes mellitusAutoinflammatory syndromesSecondary brain injury after hemorrhage
05
Safety considerations
Potential for immunosuppressionIncreased susceptibility to infection
06
Biomarkers
IL-1β levelsIL-18 levels
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