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Target intelligence / Profile preview
Neurite Outgrowth Inhibitor A (Nogo-A)
- Target
- Nogo-A
- Molecular classification
- Reticulon family member, Myelin-associated inhibitor
01
Overview
Nogo-A, also known as neurite outgrowth inhibitor A, is a member of the reticulon family (RTN4). It is a potent myelin-associated inhibitor of neurite outgrowth in the central nervous system (CNS), limiting axonal regeneration and plasticity after CNS injury. Nogo-A functions by binding to neuronal receptors (NgR1 complex), triggering intracellular signaling cascades involving RhoA, and destabilizing actin filaments at growth cones, halting further extension. Blocking antibodies against Nogo-A have shown promise in promoting axonal regeneration and compensatory sprouting following CNS lesions in animal models.
- Other names
- RTN4Reticulon 4NI-220/250
02
Mechanism of action
Blocking Nogo-A binding to NgR1 complex, thereby preventing RhoA/ROCK activation and promoting axonal regeneration.
03
Biological functions
Inhibition of neurite outgrowthRegulation of dendritic arborizationRegulation of oligodendrocyte myelin formationMaintenance of neural circuit stabilityRegulation of ER structureRegulation of amyloid precursor protein processingRegulation of cell survivalScaffolding protein
04
Disease associations
Spinal cord injuryCNS traumaNeurodegenerative diseases
05
Safety considerations
Potential for off-target effects due to widespread expression of reticulon family members.Unintended consequences of promoting excessive plasticity in the adult CNS.Possible impact on other cellular functions, such as ER structure regulation or APP processing.
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