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Non-coding Mitochondrial RNA (ncmtRNA)
- Target
- ncmtRNA
- Molecular classification
- Non-coding RNA, Long non-coding RNA (lncRNA), Circular RNA (circRNA), MicroRNA (miR)
01
Overview
Non-coding mitochondrial RNAs (ncmtRNAs) are a diverse group of RNA molecules transcribed from the mitochondrial genome that do not code for proteins. These RNAs include long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRs). They play crucial roles in regulating gene expression, maintaining cellular homeostasis, and mediating communication between mitochondria and the nucleus. Aberrant expression or function of certain mt-ncRNAs is associated with tumorigenesis due to their impact on cell division control mechanisms, making them potential biomarkers or therapeutic targets for cancer research.
- Other names
- Mitochondrial non-coding RNAmt-ncRNA
02
Mechanism of action
Modulation of gene expression, interaction with mtDNA, interaction with nuclear genome-encoded proteins
03
Biological functions
Gene expression regulationMitochondrial homeostasisOxidative phosphorylation (OXPHOS)MetabolismCell cycle regulationApoptosisRetrograde signalingMitochondria-nucleus cross-talk
04
Disease associations
CancerTumorigenesisCell cycle dysregulation
05
Safety considerations
Aberrant expression linked to tumorigenesisPotential impact on cell division control mechanisms
06
Biomarkers
lncND5lncCyt blncND6
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