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Target intelligence / Profile preview
Non-functional P2X purinoceptor 7 (nfP2X7)
- Target
- nfP2X7
- Molecular classification
- Purinergic receptor, Ligand-gated ion channel, P2X receptor family
01
Overview
The non-functional P2X7 receptor (nfP2X7) is a variant of the P2X7 receptor that, unlike its functional counterpart, does not form the large cytolytic pore upon activation by ATP. This prevents cell death through pore formation, allowing nfP2X7 expressing cells to evade immune-mediated killing. nfP2X7 is specifically expressed on malignant cells, making it a potential target for cancer immunotherapy, particularly CAR-T cell therapy. It is characterized by the exposure of the E200 epitope on its extracellular domain.
- Other names
- nf-P2X7Non-functional P2X7 receptornfP2X7RNon-functional P2X7
02
Mechanism of action
Antibody-mediated tumor cell killing, CAR-T cell-mediated tumor cell killing
03
Biological functions
Immune evasionReduced ATP-mediated cell deathTumor-associated antigen
04
Disease associations
CancerInfection
05
Safety considerations
Off-target effects on cells expressing low levels of nfP2X7, potential for cytokine release syndrome in CAR-T therapy
06
Biomarkers
E200 epitope expression
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