Non-molecular physical interaction

Non-molecular physical interaction" refers to physical effects that do not operate via specific molecular entities such as proteins, nucleic acids, or small molecules. These interactions typically include non-molecularly-resolved influences such as temperature, pressure, electromagnetic radiation, acoustic/mechanical stimuli, or physical force—none of which selectively engage a protein, enzyme, receptor, transporter, or other canonical molecular target. In the context of pharmacology or molecular biology, such designations are considered imprecise or incorrect as a target since actionable and selective drug effects require a defined molecular target (e.g., receptor, enzyme, or ion channel)[1][2]. If you are cataloging therapeutic targets, "Non-molecular physical interaction" should be flagged as an incorrect or non-selective entry, lacking molecular specificity and not corresponding to a discrete entity that could serve as a biomarker or drug target.