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Non-muscle Myosin IIA (None)
- Target
- None
- Molecular classification
- Molecular Motor Protein, Myosin, ATPase
01
Overview
Non-muscle myosin IIA (NM IIA) is a molecular motor protein that generates intracellular contractile force, drives actin cytoskeleton dynamics, and facilitates cellular processes such as cell migration, cytokinesis, adhesion, tissue morphogenesis, and maintenance of epithelial barrier function. It is a hexamer composed of two heavy chains (MYH9 gene product), two regulatory light chains, and two essential light chains. Regulation occurs primarily through phosphorylation of its regulatory light chain. Mutations in MYH9 are associated with various diseases, including MYH9-related disorders and cancer. It is an area of active research due to its involvement in cancer progression/resistance mechanisms via cytoskeletal control networks like ROCK-NMIIA signaling.
- Other names
- NM IIANMIIANon-muscle myosin heavy chain IIAMYH9
02
Mechanism of action
Inhibition of ATPase activity; modulation of phosphorylation of regulatory light chain.
03
Biological functions
Cell migrationCytokinesisEpithelial barrier formationTissue morphogenesisActin cytoskeleton dynamicsCell adhesionIntracellular contraction
04
Disease associations
MYH9-related diseaseMay-Hegglin anomalyEpstein syndromeChronic kidney diseaseNon-syndromic deafnessMacrothrombocytopeniaCancer
05
Safety considerations
Potential for off-target effects due to broad expressionComplex role in cancer (tumor suppressor vs. promoter)Limited number of direct targeting compounds currently available
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