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Target intelligence / Profile preview
Non-muscle Myosin IIB (NMIIB)
- Target
- NMIIB
- Molecular classification
- Motor protein, Actomyosin, Enzyme
01
Overview
Non-muscle myosin IIB (NMIIB) is a molecular motor protein that interacts with actin filaments to generate contractile forces within cells. It plays critical roles in cell migration, cytoskeletal organization, cytokinesis, and neuronal function, especially in stabilizing tension and guiding directional movement. NMIIB is widely expressed across human tissues, including cardiac muscle, and its dysfunction is associated with various diseases.
- Other names
- Myosin-10MYH10NM-IIBNon-muscle myosin heavy chain IIB
02
Mechanism of action
Inhibition of NMIIB ATPase activity, disruption of actin-myosin interaction, inhibition of regulatory light chain phosphorylation
03
Biological functions
Cell migrationCytoskeletal organizationCytokinesisNeurite outgrowthMuscle contraction (non-muscle)Regulation of gene expression
04
Disease associations
CardiomyopathyNeuronal development disordersCancer (potential role in metastasis)Cell polarity defects
05
Safety considerations
Potential for off-target effects due to similarity with other myosin isoformsDisruption of essential cellular processes like cell division and migration
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