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Target intelligence / Profile preview
Non-receptor Protein Tyrosine Kinase
- Molecular classification
- Enzyme, Protein Kinase, Non-receptor tyrosine kinase
01
Overview
Non-receptor protein tyrosine kinases (nRTKs) are cytosolic enzymes that catalyze the transfer of a phosphate group from ATP to tyrosine residues on substrate proteins. They play central roles in signal transduction for immune receptors and regulation of cell growth, proliferation, differentiation, adhesion, migration, and apoptosis. Dysregulation can lead to immunodeficiencies or contribute to oncogenesis. Examples include HCK, CSK, Lck, Lyn, and Zap70. They participate in immune system pathways, including chemokine and T cell receptor signaling pathways.
- Other names
- Non-specific protein-tyrosine kinaseCytoplasmic protein tyrosine kinase
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Signal transductionImmune regulationCell growthCell proliferationCell differentiationApoptosisCell migrationCell adhesion
04
Disease associations
CancerImmunodeficiencyInflammation
05
Safety considerations
Potential for off-target effects due to broad role in cellular signalingDrug resistance
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