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Target intelligence / Profile preview
Non-Receptor Tyrosine Kinase (nRTK)
- Target
- nRTK
- Molecular classification
- Enzyme, Kinase, Tyrosine Kinase, ABL family kinase, SYK family kinase, JAK family kinase, TEC family kinase, FAK family kinase, ACK family kinase, SRC family kinase, BRK/PTK6 family kinase, CSK family kinase
01
Overview
Non-receptor tyrosine kinases (nRTKs) are cytosolic enzymes that catalyze the transfer of a phosphate group from ATP to tyrosine residues on substrate proteins. Unlike receptor tyrosine kinases (RTKs), nRTKs do not possess extracellular ligand-binding or transmembrane domains. They function within the cytoplasm or are tethered to cellular membranes. They regulate cell growth, proliferation, differentiation, adhesion, migration, apoptosis, and immune responses. Dysregulation is implicated in diseases like cancer and autoimmunity.
- Other names
- Cytoplasmic tyrosine kinaseIntracellular tyrosine kinase
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Signal transductionCell growthCell proliferationCell differentiationCell adhesionCell migrationApoptosisImmune response
04
Disease associations
CancerAutoimmunityImmunodeficiency
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Safety considerations
Off-target effectsResistance development
06
Interacting drugs
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