Non-SMC condensin I complex subunit D2 (NCAPD2)

Non-SMC condensin I complex subunit D2 (NCAPD2) is a key regulatory subunit of the condensin I complex, which is crucial for mitotic chromosome condensation, proper chromosome segregation, and genomic stability during cell division[1][5][6]. NCAPD2 enables histone binding, targets the condensin complex to chromatin, and influences DNA supercoiling and decatenation in concert with DNA topoisomerases[1][6]. It is essential for the resolution of sister chromatid intertwines and plays essential roles in neurodevelopment and maintaining the correct neuron pool size[1]. NCAPD2 is implicated in multiple cancers as both a prognostic and diagnostic biomarker, and altered expression promotes tumor development and progression, especially in lung, liver, and breast cancers[2]. It may also participate in immune response modulation and neurodegenerative diseases[2]. Drugs such as topotecan display sensitivity linked to NCAPD2 expression, and its targeting poses potential safety concerns related to effects on normal cell division and neurodevelopment[2].

Other names

CAP-D2CNAP1hCAP-D2KIAA0159Chromosome-associated protein D2MCPH21XCAP-D2 homolog

Inhibition of condensin complex function (e.g., disruption of chromosome condensation or cell cycle)