Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Non-SMC condensin II complex subunit G2 (NCAPG2)
- Target
- NCAPG2
- Molecular classification
- Condensin II complex subunit, Chromosome structure/regulator, Non-SMC protein component, Other
01
Overview
Non-SMC condensin II complex subunit G2 (NCAPG2) is a regulatory protein within the condensin II complex, essential for mitotic chromosome condensation and segregation[4][3]. NCAPG2 mediates proper microtubule–kinetochore attachment by recruiting Polo-like kinase 1 (PLK1) to kinetochores, which is crucial for accurate chromosome segregation during mitosis[1][2]. It also participates in the regulation of DNA repair pathways and maintenance of genomic stability, interacting with factors such as MCPH1[3]. Loss or dysfunction of NCAPG2 disrupts chromosome condensation and can lead to aneuploidy and developmental defects. Increased expression of NCAPG2 is associated with tumorigenesis and poor prognosis, especially in certain cancers, suggesting its utility as a biomarker and a potential therapeutic target[3].
- Other names
- Condensin-2 complex subunit G2CAP-G2hCAP-G2LUZP5FLJ20311MTBchromosome-associated protein G2Leucine zipper protein 5more than blood homolog
02
Mechanism of action
null
03
Biological functions
Chromosome condensationChromosome segregationMicrotubule–kinetochore attachmentRegulation of mitosisDNA repair regulationHomologous recombinationMaintenance of genomic integrityCell division
04
Disease associations
Cancer (notably breast, colorectal, and gastric cancers)Developmental disordersTumorigenesis
05
Safety considerations
Loss or mutation causes developmental anomaliesgenomic instabilityaneuploidyimplications for toxicity due to disruption of mitosis if therapeutically inhibited
06
Biomarkers
Expression levels of NCAPG2 are proposed as potential prognostic biomarkers in certain cancers (e.g., breast, colorectal, and gastric cancer)
Beyond the preview
Go deeper on Non-SMC condensin II complex subunit G2 (NCAPG2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Non-SMC condensin II complex subunit G2 (NCAPG2).