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Target intelligence / Profile preview
Non-specific lipid-transfer protein Cit s 3 (Cit s 3)
- Target
- Cit s 3
- Molecular classification
- Other, Plant non-specific lipid-transfer protein
01
Overview
Cit s 3 is a non-specific lipid-transfer protein found in citrus fruits, classified as a plant lipid-transfer protein responsible for shuttling phospholipids and galactolipids across plant membranes and possibly involved in the biosynthesis or deposition of protective plant layers such as wax or cutin. It does not function as a recognized therapeutic target for human drugs but is clinically important as a food allergen implicated in citrus fruit allergies.
- Other names
- Cit s 3Cit s 3.0102
02
Mechanism of action
Not applicable (not a drug target)
03
Biological functions
Lipid transfer across plant membranesInvolvement in wax and cutin deposition in plants
04
Disease associations
Not directly relevant to human diseases; Cit s 3 is a plant protein, mainly known as a citrus allergen (major allergen from citrus fruits) rather than a therapeutic human target
05
Safety considerations
Allergenic potential: Major cause of allergic reactions to citrus fruits in sensitized individuals
06
Interacting drugs
None known
07
Biomarkers
Cit s 3 can serve as a biomarker for citrus fruit allergy in plant-allergic individuals
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