Non-specific stratum corneum components (SC components)

The stratum corneum is the outermost layer of the epidermis, functioning as the body's primary interface with the external environment and its main permeability barrier (StatPearls: Physiology, Stratum Corneum, 2023). It is structurally characterized by the bricks and mortar model, where protein-rich corneocytes (the bricks) are embedded in a continuous matrix of intercellular lipids (the mortar), primarily ceramides, cholesterol, and free fatty acids (Journal of Clinical Medicine, 2018). Non-specific components of this layer are the primary targets for topical emollients, humectants, and keratolytics used to treat dermatological conditions such as xerosis, atopic dermatitis, and psoriasis (PubMed: Management of Skin Barrier Dysfunction, 2021). Drugs like petrolatum act as occlusives to prevent water loss, while humectants like glycerin draw water into the stratum corneum, and keratolytics like salicylic acid promote the shedding of dead cells by disrupting intercellular adhesions (StatPearls: Keratolytic Agents, 2023). Because this target represents a complex tissue layer rather than a single molecular entity, it is often considered a non-specific pharmacological target where the goal is the restoration of physical and chemical homeostasis.

Other names

Skin barrierHorny layerCorneocytes and intercellular lipidsEpidermal barrier

Occlusion, humectancy, keratolysis, and lipid replenishment to restore skin barrier integrity and hydration.