Target intelligence / Profile preview

Non-structural maintenance of chromosomes element 1 homolog (NSMCE1)

Target: NSMCE1
Molecular classification: Other (structural maintenance of chromosomes complex component), E3 ubiquitin ligase (RING-type zinc finger-containing)

Overview

Non-structural maintenance of chromosomes element 1 homolog (NSMCE1) is a protein component of the SMC5/6 complex, involved in the maintenance of genome integrity, DNA damage response, and DNA repair. NSMCE1 contains a RING-type zinc finger domain conferring E3 ubiquitin ligase activity, and mediates protein dimerization and protein-protein interactions necessary for complex assembly. The protein is ubiquitously expressed in the nucleus across diverse tissue types and operates as a structural and regulatory element in chromosomal maintenance. Although not currently considered a direct therapeutic target, NSMCE1 is essential for cellular survival in response to genotoxic stress through its role in the repair of damaged DNA strands and may have indirect implications in diseases characterized by genomic instability.

Other names: NSMCE1Non-SMC element 1 homologNSE1HSPC333HSPC337SMC5-SMC6 complex component

Biological functions

DNA damage responseDNA repairMaintenance of genome integrityProtein dimerizationUbiquitin ligase activity

Disease associations

Other (Possible implication in genomic instability and DNA repair-related diseases, but not a primary disease marker or direct target)

Beyond the preview

Go deeper on Non-structural maintenance of chromosomes element 1 homolog (NSMCE1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Non-structural maintenance of chromosomes element 1 homolog (NSMCE1).

Explore the full profile