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Target intelligence / Profile preview
Non-voltage-operated Calcium Channel (Non-VGCC)
- Target
- Non-VGCC
- Molecular classification
- Ion channel, Ligand-gated ion channel, Store-operated calcium channel, Two-pore channel, Receptor
01
Overview
Non-voltage-operated calcium channels are a diverse group of membrane proteins that mediate calcium influx into cells independently of changes in membrane potential. These channels are activated by mechanisms such as ligand binding or depletion of intracellular calcium stores, playing critical roles in signal transduction, muscle contraction, immune cell activation, and gene expression. Examples include IP3 receptors, ryanodine receptors, store-operated CRAC channels, and other non-selective cation channels permeable to calcium.
- Other names
- Non-voltage-gated Calcium ChannelReceptor-operated Calcium ChannelLigand-gated Calcium ChannelStore-operated Calcium ChannelSOCCCRAC
02
Mechanism of action
Modulation of calcium influx
03
Biological functions
Signal transductionCalcium signalingMuscle contractionImmune cell activationRegulation of gene expressionCalcium homeostasis
04
Disease associations
CancerInflammationNeurodegenerative diseaseCardiovascular diseaseImmune disorders
05
Safety considerations
Off-target effects due to broad expressionPotential for disrupting calcium homeostasisSelectivity challenges in targeting specific channel subtypes
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