Nonclaret disjunctional motor protein (Ncd)

Nonclaret disjunctional motor protein (Ncd) is a kinesin-related microtubule motor protein found in Drosophila melanogaster and is essential for proper chromosome distribution during meiosis and early mitosis[1][2][3]. Ncd translocates along microtubules toward their minus ends, in contrast to most kinesins which move toward the plus end[1][2][4]. Ncd consists of three main domains: an N-terminal "tail," a coiled-coil stalk, and a C-terminal motor domain that hydrolyzes ATP for motility[1]. It plays a critical mechanochemical role in bundling and sliding microtubules and in organizing the mitotic spindle[3][4]. Ncd is a member of the kinesin-14 family and, unlike human motor proteins, it is not itself a direct therapeutic target; its primary relevance is to basic research in cell division and motor protein mechanism[1][2][3]. **Note:** - There is no evidence that Ncd is considered a current or potential therapeutic target in humans, nor is it associated with drug action, biomarkers, or disease beyond its function in Drosophila and related model organisms[1][2][3]. - If the user seeks information relating to human disease or drug targets, a related human kinesin-14 motor protein (e.g., KIFC1) may be more relevant.

Other names

Ncdnonclaret disjunctional proteinkinesin-like proteinDrosophila kinesin-14