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Noncompact myelin-associated protein (NCMAP)
- Target
- NCMAP
- Molecular classification
- Other (structural protein; not a receptor, enzyme, transporter, or transcription factor)
01
Overview
Noncompact myelin-associated protein (NCMAP) is a glycosylated protein predominantly expressed in the peripheral nervous system, where it functions as a structural constituent of the myelin sheath. It is essential for the formation, stability, and maintenance of myelin, especially in the peripheral nervous system, and is particularly localized to noncompact regions of myelin such as the Schmidt-Lanterman incisures and paranodal regions of axons. NCMAP is not recognized as a classic drug target, receptor, or enzyme, but mutations and differential expression have been associated with certain neurological syndromes[1][2][3][6][7][9].
- Other names
- C1orf130MP11FLJ42528myelin protein of 11 kDa
02
Biological functions
Myelin sheath formationPositive regulation of myelinationPeripheral nervous system myelin formationStructural constituent of myelin sheath
03
Disease associations
Neurodevelopmental disorders (association with conditions such as Dieulafoy Lesion and familial febrile seizures[1][7])supported links to neurological diseases
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