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Nonsense-mediated mRNA Decay Pathway (NMD)

Target: NMD
Molecular classification: Pathway, RNA degradation pathway

Overview

Nonsense-mediated mRNA decay (NMD) is a highly conserved surveillance pathway present in all eukaryotes. Its primary function is to maintain the fidelity of gene expression by identifying and degrading messenger RNA (mRNA) transcripts that contain premature termination codons (PTCs), also known as nonsense mutations. By eliminating these faulty mRNAs, NMD prevents the synthesis of truncated proteins that could be deleterious or have dominant-negative effects on cellular function.

Biological functions

mRNA surveillanceGene regulationQuality control of mRNARegulation of apoptosisRegulation of differentiationResponse to environmental changes

Disease associations

Genetic disorders (when defective)

Safety considerations

Excessive NMD activity can degrade necessary transcriptsInsufficient NMD activity can allow harmful truncated proteins to accumulate

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