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Target intelligence / Profile preview
Nonspecific Cross-Reacting Antigen 95 (NCA-95)
- Target
- NCA-95
- Molecular classification
- Carcinoembryonic antigen-related glycoprotein, Immunoglobulin superfamily member, Cell adhesion molecule
01
Overview
Nonspecific Cross-Reacting Antigen 95 (NCA-95) is a cell surface glycoprotein belonging to the carcinoembryonic antigen (CEA) gene family and the immunoglobulin supergene family. Primarily expressed on granulocytes, it plays roles in cell adhesion, immune response, and bacterial recognition. It is implicated in various cancers and inflammatory conditions, serving as a potential biomarker.
- Other names
- CD66bCEACAM8CGM6CEA-related cell adhesion molecule 8
02
Mechanism of action
Antibody binding to NCA-95 triggers secondary granule release via Ca²⁺ fluxes dependent on protein kinase activity.
03
Biological functions
Cell adhesionBacterial bindingReceptor activitySignal transductionImmune responseLeukocyte function modulation
04
Disease associations
CancerInflammationInfection
05
Biomarkers
Cancer diagnosis and prognosisMonitoring disease progressionResponse to therapy
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