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Target intelligence / Profile preview
Middle East Respiratory Syndrome Coronavirus Main Protease (Mpro)
- Target
- Mpro
- Molecular classification
- Enzyme, Cysteine protease
01
Overview
The main protease of the Middle East respiratory syndrome coronavirus (MERS-CoV), also known as Mpro or 3C-like protease (3CLpro), is a cysteine protease crucial for viral replication and pathogenesis. It cleaves the large viral replicase polyproteins pp1a and pp1ab at multiple sites, generating functional non-structural proteins. MERS-CoV Mpro also cleaves cellular substrates like MAVS, suppressing innate immune responses. It functions as a homodimer and is a promising target for antiviral drug development.
- Other names
- MERS-CoV Mpro3C-like protease3CLproNonstructural Protein 5Nsp5
02
Mechanism of action
Inhibition of MERS-CoV Mpro prevents viral polyprotein processing and replication.
03
Biological functions
Polyprotein processingViral replicationImmune evasion
04
Disease associations
Infection
05
Safety considerations
Off-target effects (although considered minimal due to unique substrate specificity)Potential for resistance development
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