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Target intelligence / Profile preview
Nonstructural protein 5A of hepatitis C virus (NS5A)
- Target
- NS5A
- Molecular classification
- Viral nonstructural protein, Phosphoprotein, Zinc-binding protein
01
Overview
HCV's nonstructural protein 5A is a central regulator coordinating multiple aspects of the virus life cycle—including genome replication complex formation on ER membranes—and modulating cellular environments conducive to persistent infection. Its unique structure-function relationships make it both scientifically significant and clinically actionable as an antiviral target.
02
Mechanism of action
Inhibition of NS5A protein function, blocking viral replication and assembly
03
Biological functions
Viral RNA replicationVirion assemblyModulation of host signalingRegulation of calcium levelsInduction of oxidative stressActivation of transcription factors
04
Disease associations
InfectionLiver pathogenesisChronic hepatitis C infection
05
Interacting drugs
NS5A inhibitors
06
Biomarkers
Interferon sensitivity-determining region (ISDR)
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