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Nonstructural protein 5B (NS5B)

Target: NS5B
Molecular classification: Enzyme, RNA-dependent RNA polymerase

Overview

Nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRp) essential for the replication of the hepatitis C virus (HCV). It catalyzes the synthesis of new viral RNA strands using the existing viral genome as a template. NS5B is a key target for direct-acting antiviral (DAA) drugs.

Other names: HCV NS5BHepatitis C virus NS5BRNA-dependent RNA polymerase (RdRp)

Mechanism of action

Inhibition of RNA-dependent RNA polymerase activity, thereby blocking viral replication.

Biological functions

Viral RNA replicationViral genome amplification

Disease associations

Hepatitis C virus infection

Safety considerations

Drug resistance mutationsPotential for drug interactions

Interacting drugs

Sofosbuvir

1 more in the full profile.

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