Target intelligence / Profile preview

Nonstructural Protein 5B (NS5B) Polymerase (NS5B)

Target: NS5B
Molecular classification: Enzyme, RNA-dependent RNA polymerase

Overview

Nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRp) encoded by the hepatitis C virus (HCV). It is essential for viral replication, catalyzing the synthesis of new viral RNA genomes using the positive-sense viral RNA as a template. NS5B is a key component of the HCV replication complex and serves as a primary target for antiviral drug development due to its unique structure and function compared to host cellular polymerases.

Mechanism of action

Inhibition of RNA-dependent RNA polymerase activity, leading to termination of viral RNA synthesis

Biological functions

RNA replicationViral genome synthesis

Disease associations

InfectionHepatitis C

Interacting drugs

Sofosbuvir

2 more in the full profile.

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