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Target intelligence / Profile preview
NOP protein chaperone 1 (NOPCHAP1)
- Target
- NOPCHAP1
- Molecular classification
- Other (Chaperone/assembly cofactor), Not a receptor, enzyme, transporter, ion channel, or transcription factor
01
Overview
NOP protein chaperone 1 is an intrinsically disordered protein that serves as a client-loading cofactor for the PAQosome (HSP90/R2TP complex and prefoldin-like module) to facilitate the assembly of box C/D small nucleolar ribonucleoproteins. It acts specifically by bridging NOP58 and the RUVBL1/2 AAA+ ATPase complex, ensuring selective incorporation of NOP58 and proper snoRNP biogenesis. NOPCHAP1 shows robust binding to both yeast and human NOP58 proteins but minimal interaction with homologous proteins NOP56 and PRPF31. This selectivity supports proper ribonucleoprotein complex formation in the nucleus. Knockout studies indicate NOPCHAP1 is dispensable for cell growth and cell cycle progression but is important for maintaining NOP58 protein levels and assembly during early steps in snoRNP biogenesis.
- Other names
- NOPCHAP1C12orf45MGC40397DDSR1DNA damage-sensitive RNA 1NOP protein chaperone 1uncharacterized protein C12orf45
02
Mechanism of action
Not applicable (No direct drug mechanisms described for this protein)
03
Biological functions
Box C/D snoRNP assemblyChaperoning and bridging NOP58 to RUVBL1/2 AAA+ ATPase complex and PAQosomeAssisting stabilization and specific selection of NOP58 versus related proteinsIntrinsically disordered protein aiding protein-protein interactions in ribonucleoprotein complexes
04
Disease associations
Other (No direct disease associations established yet; knockout does not impact cell cycle but may affect ribonucleoprotein biogenesis)
05
Safety considerations
None reported (No known therapeutic safety concerns or challenges as it is not a drug target)
06
Interacting drugs
None known (No drugs identified that interact directly with NOPCHAP1)
07
Biomarkers
None established (No validated biomarkers for patient selection or monitoring related to NOPCHAP1)
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