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NOP14 antisense RNA 1 (NOP14-AS1)

Target: NOP14-AS1
Molecular classification: Long non-coding RNA (lncRNA), Antisense RNA

Overview

NOP14 antisense RNA 1 is a long non-coding RNA gene located on human chromosome 4 (4q13.3), transcribed antisense to the protein-coding gene NOP14. As an lncRNA, NOP14-AS1 does not encode a protein but is believed to play a regulatory role in gene expression, primarily affecting expression of its sense gene (NOP14) and potentially influencing biological pathways involved in cell proliferation. Recent research suggests involvement in certain cancers, such as glioma and chordoma, but its precise molecular function and mechanistic role remain under investigation.

Other names: C4orf10RES4-24ENSG00000249673HGNC:20205NR_015453

Mechanism of action

Not applicable

Biological functions

Regulates gene expression (as an antisense RNA, typically modulates the expression of the overlapping or nearby gene, in this case NOP14)May be involved in regulation of cell proliferation and migration (suggested in disease contexts)

Disease associations

Cancer (including glioma susceptibility, regulation in pancreatic cancer cell proliferation and migration, possibly involvement in clivus chordoma)

Safety considerations

None established

Interacting drugs

None known

Biomarkers

None established for clinical use

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