NOP53 antisense RNA 1 (NOP53-AS1)

NOP53 antisense RNA 1 (NOP53-AS1) is a long noncoding antisense RNA transcribed from the opposite strand of the NOP53 gene locus. Members of the antisense lncRNA family, such as NOP53-AS1, typically regulate their sense protein-coding gene (here, NOP53/GLTSCR2) through diverse mechanisms including chromatin remodeling, transcriptional control, mRNA stability, and modulation of translation. Antisense lncRNAs are often involved in cell proliferation, apoptosis, and metastasis, frequently functioning as either tumor suppressors or oncogenes, although specific data for NOP53-AS1 are lacking in the provided literature. Like other antisense lncRNAs, NOP53-AS1 may be differentially expressed in cancer and might play a regulatory role in tumorigenesis, but its clinical significance and functional impacts are not yet well established[2]. If you meant to inquire about the protein-coding gene NOP53 (GLTSCR2), which is a nucleolar protein with tumor suppressor function and is directly involved in p53 signaling and ribosome biogenesis, please clarify, as that is a distinct and better-characterized molecular entity[5].

Other names

GLTSCR2-AS1CTD-2571L23.6GLTSCR2 antisense RNA 1NOP53-AS1

None directly reported for drugs; possible mechanisms by which modulation could impact disease include regulation of gene transcription, epigenetic modulation, or RNA stability