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Noradrenergic signaling
- Molecular classification
- G protein-coupled receptor signaling pathway, Neurotransmitter signaling pathway
01
Overview
Noradrenergic signaling refers to the physiological processes mediated by norepinephrine (also known as noradrenaline), a key neurotransmitter and hormone in both the central and peripheral nervous systems. Norepinephrine is crucial for regulating arousal, attention, stress responses, cognitive function, cardiovascular activity, and energy mobilization. It encompasses all molecular components mediating norepinephrine’s actions at its target sites across tissues.
- Other names
- Norepinephrine signalingNoradrenaline signaling
02
Mechanism of action
Acts via GPCRs with diverse downstream effects depending on receptor subtype/location. Presynaptic inhibition (α₂), postsynaptic excitation/hyperpolarization (α₁/β/α₂), modulation of glial Ca²⁺ signals.
03
Biological functions
Alertness/arousalAttentionStress responseMood/cognition modulationCardiovascular controlNeurovascular couplingSignal transduction
04
Disease associations
Mood/anxiety disordersADHDAddiction/substance use disorder vulnerabilityNeurodegeneration
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