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Target intelligence / Profile preview
Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)
- Target
- NDRI
- Molecular classification
- Pharmacologic substance, Reuptake Inhibitor
01
Overview
Norepinephrine-dopamine reuptake inhibitors (NDRIs) are a class of medications that work by inhibiting the reuptake of norepinephrine and dopamine, increasing the extracellular levels of these neurotransmitters and enhancing noradrenergic and dopaminergic neurotransmission in the brain. They are used to treat a variety of conditions, including depression, ADHD, and nicotine addiction.
- Other names
- Norepinephrine and Dopamine Reuptake InhibitorNorepinephrine-Dopamine Transport Blocker
02
Mechanism of action
Inhibits the reuptake of norepinephrine and dopamine by blocking the norepinephrine transporter (NET) and dopamine transporter (DAT), increasing the concentration and prolonging the activity of these neurotransmitters in the synaptic cleft.
03
Biological functions
Increase synaptic norepinephrine levelsIncrease synaptic dopamine levelsEnhance noradrenergic neurotransmissionEnhance dopaminergic neurotransmission
04
Disease associations
Major Depressive DisorderAttention Deficit Hyperactivity Disorder (ADHD)Seasonal Affective DisorderNicotine AddictionNarcolepsyAnxiety DisordersSSRI-associated sexual dysfunctionBipolar Depression
05
Safety considerations
Potential side effects distinct from SSRIsRequires monitoring for adverse effects
06
Interacting drugs
Bupropion
5 more in the full profile.
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