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Target intelligence / Profile preview
Norepinephrine Receptor Alpha 2A Subunit (None)
- Target
- None
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The norepinephrine receptor alpha 2A subunit (α2A-adrenergic receptor or ADRA2A) is a G protein-coupled receptor (GPCR) that plays a critical role in regulating neurotransmitter release and mediating physiological responses to catecholamines. It acts as an autoreceptor on presynaptic sympathetic nerve terminals to inhibit norepinephrine release and is also found postsynaptically in the CNS where it modulates cognitive functions. Drugs targeting this receptor are used for sedation, analgesia, hypertension, and ADHD.
- Other names
- α2A-Adrenergic ReceptorADRA2Aα₂ΑADRA2Αalpha 2a adrenergic
02
Mechanism of action
Gi/o protein-coupled receptor activation leading to inhibition of adenylyl cyclase and decreased cAMP production.
03
Biological functions
Signal transductionInhibition of neurotransmitter releaseModulation of neuronal excitabilityRegulation of sympathetic tone
04
Disease associations
HypertensionADHDPain (analgesia)Sedation
05
Safety considerations
SedationHypotension
06
Interacting drugs
Norepinephrine
9 more in the full profile.
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