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Norepinephrine Transporter (NET)
- Target
- NET
- Molecular classification
- Transporter, Solute Carrier Family 6 Member 2, Neurotransmitter Transporter, Sodium/chloride-dependent neurotransmitter transporter
01
Overview
The norepinephrine transporter (NET), also known as the noradrenaline transporter (NAT), is a membrane protein responsible for the reuptake of synaptically released norepinephrine (NE) into presynaptic noradrenergic neurons. This process serves as the primary mechanism for terminating noradrenergic signaling. NET is a member of the solute carrier family 6 (SLC6A2) and its function is regulated by post-translational modifications and other cellular signaling events. Inhibition of NET is a therapeutic strategy for depression and ADHD.
- Other names
- Noradrenaline TransporterNATSLC6A2
02
Mechanism of action
Inhibition of norepinephrine reuptake, leading to increased synaptic norepinephrine levels.
03
Biological functions
Norepinephrine reuptakeRegulation of synaptic norepinephrine concentrationTermination of noradrenergic signalingModulation of cardiovascular function
04
Disease associations
DepressionAttention Deficit Hyperactivity Disorder (ADHD)PainNeuropsychiatric disorders
05
Safety considerations
Cardiovascular side effectsPotential for drug abuseSide effects associated with increased norepinephrine levels (e.g., anxiety, insomnia)
06
Interacting drugs
Desipramine
3 more in the full profile.
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