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Target intelligence / Profile preview
Norepinephrine transporter protein (NET)
- Target
- NET
- Molecular classification
- Transporter, Neurotransmitter:sodium symporter
01
Overview
The norepinephrine transporter (NET), encoded by the SLC6A2 gene, is a membrane protein responsible for the reuptake of synaptically released norepinephrine from the synaptic cleft back into presynaptic neurons. This process terminates the action of norepinephrine and maintains neurotransmitter homeostasis. NET is a target for many antidepressants and psychostimulant drugs, and its dysregulation is implicated in several neuropsychiatric disorders.
- Other names
- NET1NAT1Sodium-dependent noradrenaline transporterSolute carrier family 6 member 2SLC6A2
02
Mechanism of action
Inhibition of norepinephrine reuptake
03
Biological functions
Norepinephrine reuptakeNeurotransmitter homeostasisTermination of noradrenergic signaling
04
Disease associations
ADHDDepressionPanic disorderPostural orthostatic tachycardia syndrome (POTS)Chronic painMigraine headachesObesity-related syndromesAcute painCorneal diseaseGlaucomaNicotine use disorderPainStomach cancer
05
Safety considerations
Potential for dysregulation or altered expression/function leading to neuropsychiatric disorders
06
Interacting drugs
Tricyclic antidepressants
3 more in the full profile.
07
Biomarkers
Genetic polymorphisms in SLC6A2 (e.g., T283M, V245I, rs5569)Epigenetic changes (e.g., hypermethylation in promoter regions)
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