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Target intelligence / Profile preview
Norepinephrine Transporter Protein 1 (NET)
- Target
- NET
- Molecular classification
- Transporter, Sodium:neurotransmitter symporter family
01
Overview
The norepinephrine transporter (NET), encoded by the SLC6A2 gene, is a multi-pass membrane protein responsible for the reuptake of norepinephrine into presynaptic nerve terminals. This process regulates norepinephrine homeostasis in both the central and peripheral nervous systems. Dysregulation or genetic variation in NET has been implicated in several conditions, including ADHD, depression, and pain disorders. NET is a target for many antidepressants and psychostimulant drugs.
- Other names
- SLC6A2Sodium-dependent noradrenaline transporterNET1NAT1
02
Mechanism of action
Inhibits norepinephrine reuptake by binding to the NET protein and blocking the transport of norepinephrine from the synaptic cleft back into the presynaptic neuron.
03
Biological functions
Norepinephrine reuptakeNeurotransmitter homeostasisRegulation of noradrenergic neurotransmissionDopamine transport
04
Disease associations
Attention deficit hyperactivity disorderDepressionAcute/chronic painMigraineOrthostatic intolerance/postural tachycardiaPanic disorderObesityNicotine use disorderGlaucomaCorneal diseaseStomach cancer
05
Safety considerations
Potential for altered activity or cell surface expression levels with chronic drug exposureEpigenetic regulation affecting expression levelsCardiac effects with certain drugs
06
Interacting drugs
Tricyclic antidepressants
1 more in the full profile.
07
Biomarkers
rs5569
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