Target intelligence / Profile preview

Normal metabolites

Molecular classification
Other (metabolite)
01

Overview

Normal metabolites are small molecules that are the intermediates or end products of normal metabolic processes within cells. They are not a single molecule but rather a class of compounds that includes amino acids, nucleotides, sugars, lipids, organic acids, vitamins, and others[1][3][7][8]. Primary metabolites are directly involved in growth, development, and reproduction and are essential for normal physiological function, while secondary metabolites often have ecological or specialized roles[3][7][9]. The human body contains thousands of metabolites, and their presence, absence, or concentration changes form the basis of metabolic profiling and biomarker discovery[1][4][10]. Metabolites regulate biological pathways, serve as signaling molecules, alter protein activities, and are central to homeostasis, but "normal metabolites" as a collective is not a druggable target, receptor, or enzyme, and so is not classified as a therapeutic molecular target[1][2][4][5].

Other names
metabolitesprimary metabolitessecondary metabolitesmetabolic intermediates
02

Biological functions

Energy productionBiosynthesis of macromolecules (proteins, nucleic acids, lipids, carbohydrates)Cellular signalingStructural componentsRedox balanceRegulation of enzyme activity
03

Disease associations

Biomarkers for various diseases (cancer, cardiovascular disease, metabolic disorders, neurodegenerative diseases, etc.)Dysfunction can be involved in pathogenesis of many conditions (e.g., inborn errors of metabolism, metabolic syndrome, etc.)
04

Biomarkers

Various (depending on individual metabolite; e.g., lactic acid, glucose, uric acid, amino acids)

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