Target intelligence / Profile preview

Norovirus (NV)

Target
NV
Molecular classification
Virus, RNA virus, Caliciviridae, Non-enveloped virus
01

Overview

Norovirus is a highly contagious RNA virus and the leading cause of acute gastroenteritis worldwide. It infects enterocytes in the small intestine, causing symptoms such as vomiting and diarrhea. Transmission occurs through direct contact, contaminated food or water, and contaminated surfaces. Prevention relies on hygiene practices like frequent handwashing.

Other names
Norwalk virusWinter vomiting diseaseStomach flu
02

Mechanism of action

N/A - No specific antiviral treatments available.

03

Biological functions

Viral replicationInfection of enterocytesInduction of gastroenteritis
04

Disease associations

GastroenteritisFoodborne illnessOutbreaks in closed environmentsDehydration
05

Safety considerations

Dehydration, especially in vulnerable populations (young children, elderly, immunocompromised)Potential for chronic infection and malabsorption syndromes in immunocompromised patientsHigh transmissibility and potential for large-scale outbreaks

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