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Target intelligence / Profile preview
Norovirus 3C-like Protease (3CLpro)
- Target
- 3CLpro
- Molecular classification
- Enzyme, Protease, Cysteine protease
01
Overview
The Norovirus 3C-like protease (3CLpro), also known as NS6 protease, is a cysteine protease essential for norovirus replication. It cleaves the viral polyprotein into functional non-structural proteins, making it a crucial target for antiviral drug development. Inhibition of this protease blocks viral replication. The enzyme has a chymotrypsin-like fold with two domains and a catalytic dyad composed of Cys139 and His30. Extensive efforts are focused on developing small-molecule inhibitors that bind to the active site and block enzymatic activity.
- Other names
- NS6 proteaseNorovirus main proteaseNorovirus major proteaseNorovirus chymotrypsin-like protease
02
Mechanism of action
Inhibition of viral polyprotein processing
03
Biological functions
Viral polyprotein processingViral replication
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects due to homology with host proteasesDevelopment of resistance
06
Interacting drugs
GC376
1 more in the full profile.
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