Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Norovirus Capsid Protein (VP1)
- Target
- VP1
- Molecular classification
- Structural protein, Viral capsid protein
01
Overview
The norovirus capsid protein, also known as VP1, is the major structural protein forming the outer shell of noroviruses. It plays a central role in viral assembly, host cell recognition, and immune response evasion. The capsid is composed of 180 copies of VP1 arranged in a T=3 icosahedral symmetry. Each VP1 monomer (~58–60 kDa) consists of three main regions: N-terminal arm (N), Shell domain (S) and Protruding domain (P). The S domain mediates formation of the interior shell; both S and P domains are essential for proper capsid assembly. The P2 subdomain binds to histo-blood group antigens (HBGAs), which serve as attachment factors or receptors on host cells.
- Other names
- VP1Major capsid proteinNorovirus VP1Norwalk virus capsid protein
02
Mechanism of action
Attachment inhibition (potential)
03
Biological functions
Capsid assemblyHost cell recognitionViral attachmentImmune response inductionViral encapsidation
04
Disease associations
InfectionGastroenteritis
Beyond the preview
Go deeper on Norovirus Capsid Protein (VP1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Norovirus Capsid Protein (VP1).