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Target intelligence / Profile preview
Norovirus Capsid Protein VP1 (VP1)
- Target
- VP1
- Molecular classification
- Structural protein, Capsid protein
01
Overview
Norovirus capsid protein VP1 is the major structural protein forming the outer shell of noroviruses, a leading cause of acute viral gastroenteritis. VP1 self-assembles into an icosahedral capsid and interacts with host cell receptors such as histo-blood group antigens (HBGAs). The P2 subdomain mediates HBGA binding, a key determinant of strain-specific infectivity. Sequence diversity in P2 contributes to antigenic variation and immune evasion. VP1 is a key target for vaccine development, with virus-like particles (VLPs) based on VP1 showing promise as immunogens.
- Other names
- Norovirus capsid proteinVP1 capsid proteinNorovirus major capsid protein
02
Mechanism of action
N/A
03
Biological functions
Capsid assemblyHost cell bindingViral entryImmune evasionViral genome packaging
04
Disease associations
Viral gastroenteritis
05
Safety considerations
Potential for antigenic drift and immune evasionVariability in HBGA binding profiles among strains
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