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Target intelligence / Profile preview
Norovirus GI.1 major capsid protein VP1
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The Norovirus GI.1 major capsid protein VP1 is the principal structural protein forming the outer shell of the norovirus particle. It self-assembles into virus-like particles (VLPs) and mediates initial attachment to host cells by binding histo-blood group antigens (HBGAs). It is a target for vaccine and diagnostic development.
02
Mechanism of action
N/A (Targeted by vaccine development, not small molecule drugs)
03
Biological functions
Viral capsid formationHost cell attachmentReceptor binding (HBGAs)VLP assemblyAntigen presentation
04
Disease associations
InfectionGastroenteritis
05
Safety considerations
Antigenic drift/immune evasionPotential for strain-specific immunity
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