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Target intelligence / Profile preview
Norovirus GI.1 Virus-Like Particle (None)
- Target
- None
- Molecular classification
- Virus-Like Particle, Capsid Protein, Recombinant Protein
01
Overview
The Norovirus GI.1 virus-like particle (VLP) is a recombinant, non-infectious structure that mimics the native norovirus capsid but lacks viral genetic material and non-structural proteins. It is composed of the VP1 capsid protein, which self-assembles into an icosahedral shell. VLPs are used as surrogates to study virus attachment, entry mechanisms, immunogenicity, and environmental stability. They bind to histo-blood group antigens (HBGAs) via the P2 domain of VP1 and can elicit genotype-specific immune responses. GI.1 VLPs are stable within a pH range of 4.0 to 8.0 and are produced recombinantly for research purposes, including vaccine development and serological assays.
- Other names
- Norwalk virus GI.1 VLPGI.1 VLPNorovirus VLP GI.1
02
Mechanism of action
N/A
03
Biological functions
Antigen presentationImmunogenReceptor binding surrogateDiagnostic reagent
04
Disease associations
Gastroenteritis researchVaccine development
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