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Target intelligence / Profile preview
Notch 3 Receptor (NOTCH3)
- Target
- NOTCH3
- Molecular classification
- Receptor, Single-pass transmembrane protein
01
Overview
The Notch 3 receptor is a single-pass transmembrane protein that functions as a receptor in the highly conserved Notch signaling pathway. It plays critical roles in cell fate determination, vascular smooth muscle cell (VSMC) function, and tissue homeostasis. Mutations in NOTCH3 are associated with CADASIL and other diseases. It can act as an oncogene or tumor suppressor depending on the cancer context.
- Other names
- CADASIL gene/proteinCASILNeurogenic locus notch homolog protein 3NOTC3_HUMAN
02
Mechanism of action
Antibody-drug conjugate targeting Notch3.
03
Biological functions
Cell fate determinationVascular smooth muscle cell functionTissue homeostasisCell differentiationCell proliferationCell survivalTranscription regulation
04
Disease associations
CADASILAlzheimer's DiseaseLateral Meningocele SyndromePulmonary Arterial HypertensionCancer
05
Safety considerations
Potential for off-target effects due to widespread Notch signaling involvement in development and tissue homeostasis.Complex and context-dependent role in cancer (oncogene or tumor suppressor).
06
Interacting drugs
PF‑06650808
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