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Target intelligence / Profile preview
Notch 4 Receptor (NOTCH4)
- Target
- NOTCH4
- Molecular classification
- Receptor, Type I transmembrane protein, Notch receptor family
01
Overview
The Notch 4 receptor is a type I transmembrane protein and a member of the Notch family of receptors. It plays a critical role in cell fate decisions during development and in adult tissues. NOTCH4 acts as a receptor for membrane-bound ligands, triggering proteolytic cleavage and release of its intracellular domain to modulate gene expression in the nucleus. Dysregulation of NOTCH4 has been associated with susceptibility to schizophrenia, hematologic cancers, and solid tumors, including breast and pancreatic cancer.
- Other names
- Neurogenic locus notch homolog protein 4
02
Mechanism of action
Ligand binding to NOTCH4 triggers proteolytic cleavage and release of its intracellular domain, which translocates to the nucleus to modulate gene expression via the CBF1/RBPJκ complex.
03
Biological functions
Cell fate determinationDevelopmental processesImmune modulationTranscriptional regulationRegulation of vascular developmentRegulation of renal developmentRegulation of hepatic developmentHematopoietic stem cell maintenance and differentiation
04
Disease associations
Schizophrenia susceptibilityHematologic cancersBreast cancerPancreatic cancerSchizoaffective disorder
05
Safety considerations
Aberrant NOTCH4 signaling can contribute to tumor progression and therapy resistance.
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