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Target intelligence / Profile preview
NOTCH regulated ankyrin repeat protein (NRARP)
- Target
- NRARP
- Molecular classification
- Ankyrin repeat-containing protein, Transcription factor regulator
01
Overview
NRARP is a protein that functions as a feedback inhibitor of the Notch signaling pathway. It interacts with components of the Notch transcriptional activation complex, specifically NICD and RBPJ, inhibiting the expression of Notch target genes. It also integrates signals from the Wnt pathway, playing a role in angiogenesis and vascular development. Dysregulation of NRARP has been implicated in spondylocostal dysostosis and certain cancers, including leukemia and breast cancer.
- Other names
- NOTCH-regulated ankyrin repeat protein
02
Mechanism of action
Inhibits CBF-1-mediated transcriptional activation by binding to NICD and RBPJ, potentially promoting NICD degradation.
03
Biological functions
Feedback inhibition of Notch signalingRegulation of cell fate determinationIntegration of Notch and Wnt signalingRegulation of angiogenesisRegulation of endothelial cell proliferationRegulation of hematopoietic stem cell fate
04
Disease associations
Spondylocostal dysostosisT-cell Acute Lymphoblastic LeukemiaBreast Cancer
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