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Notch Signaling Pathway (Notch)
- Target
- Notch
- Molecular classification
- Cell Signaling Pathway, Receptor-Ligand Interaction, Transcription Factor Activation
01
Overview
The Notch signaling pathway is a highly conserved cell signaling system that regulates gene expression and controls multiple processes of cell differentiation during embryonic development and adult tissue homeostasis. Activation involves ligand binding, proteolytic cleavage of Notch receptors, nuclear translocation of NICD, and transcriptional activation of target genes. Misregulation is linked to various diseases including cancers and developmental syndromes.
- Other names
- Notch pathwayNotch signaling
02
Mechanism of action
Modulation of Notch receptor cleavage and downstream signaling.
03
Biological functions
Cell fate decisionsCell proliferationDifferentiationApoptosisCell-cell communicationNeuronal developmentCardiovascular system developmentPancreatic lineage specificationGut epithelial lineage choicesHematopoietic stem cell expansionOsteoblastic commitmentBone regenerationT-cell lineage commitmentMammary gland development
04
Disease associations
CancerDevelopmental syndromesT-cell acute lymphoblastic leukemia/lymphomaAlagille syndromeCADASILOsteoporosis
05
Safety considerations
Off-target effects due to broad expression of Notch receptorsPotential for developmental toxicityImmune-related adverse eventsDysregulation of tissue homeostasis
06
Interacting drugs
Gamma-secretase inhibitors
1 more in the full profile.
07
Biomarkers
NICD levelsHES/HEY gene expression
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