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Target intelligence / Profile preview
Novel Cancer-Specific Antigen Pair
- Molecular classification
- Cell Surface Protein, Tumor-Specific Antigen
01
Overview
A novel cancer-specific antigen pair consists of two antigens that are uniquely or predominantly expressed on cancer cells, with minimal expression on normal tissues. This combinatorial approach is used to improve the specificity and efficacy of targeted therapies like CAR-T cell therapy and antibody-drug conjugates, enhancing tumor discrimination and reducing off-tumor toxicity. Examples of antigen pairs include CEA/MSLN or KREMEN2 combined with a clinical target.
02
Mechanism of action
Binding to antigen pair leads to targeted cell killing or immune activation (e.g., CAR-T cell activation). Logic-gated therapies increase specificity.
03
Biological functions
Cell SurvivalImmune EvasionTumor VascularizationTarget for Immunotherapy
04
Disease associations
Cancer
05
Safety considerations
Off-target toxicityCytokine Release Syndrome (CRS)On-target, off-tumor effectsImmunogenicity
06
Interacting drugs
A2B530
2 more in the full profile.
07
Biomarkers
Expression levels of individual antigens within the pairCo-expression patterns of antigen pair in tumor tissueHLA-A02 loss
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